Ulrich Desselberger


Short bio:

After studying medicine in Germany (Frankfurt/Main, Marburg, Berlin) and France (Paris) and completing a M.D. thesis in Berlin (Free University, 1967), I trained as a virologist at Hannover Medical School (Germany) (Dr Joachim Drescher) and gained academic qualification by habilitation in 1976 with a thesis on influenza viruses. After further research on influenza viruses at Mt Sinai Medical Center, New York, NY, USA (Dr Peter Palese, 1977-1979), I was appointed Senior Lecturer and Honorary Consultant at the University of Glasgow, Scotland, UK (1980-86), where I started rotavirus research. In 1987 I moved to Birmingham, U.K., as Consultant Virologist and Director of the Regional Virus Laboratory. Since 1990 I served as Consultant Virologist and Director of the Clinical Microbiology and Public Health Laboratory, Addenbrooke’s Hospital, Cambridge, UK (1990-2002). After retiring from this post, I continued carrying out rotavirus research in laboratories in France (Dr J Cohen, 2002-2004), Italy (Dr O Burrone, 2005-2006), and in Cambridge (at the Department of Medicine since 2007; Honorary Senior Visiting Fellow since 2014).


Recent Publications:

Desselberger U, Goodfellow I. Noroviruses: a global cause of acute gastroenteritis.Lancet Infect Dis. 2014; 14(8): 664-5.

Desselberger U. Rotaviruses. Virus Res 2014; 190: 75-96.

Clarke E, Desselberger U. Correlates of protection against rotavirus disease and the factors influencing protection in low-income settings. Mucosal Immunol 2015; 8(1): 1-17.

CheungW, GauntE, LeverA, DesselbergerU. Rotavirus replication: the role of lipid droplets. In: Viral Gastroenteritis: Molecular biology, pathogenesis, epidemiology and vaccine development. Edited by L Svensson, U Desselberger, HB Greenberg, MK Estes, pp 175-187. Elsevier Academic Press, Amsterdam, etc., 2016.

Bwogi J, Malamba S, Kigozi B, Namuwulya P, Tushabe P, Kiguli S, Byarugaba DK,  Desselberger U, Iturriza-Gomara M, Karamagi C.The epidemiology of rotavirus disease in under-five year old children hospitalized with acute diarrhoea in central Uganda, 2012-2013. Arch Virol 2016; 161(4): 999-1003.

Lever A, Desselberger U. Rotavirus replication and the role of cellular lipid droplets: new therapeutic targets? J Formos Med Assoc 2016; 115(6): 389-94.

Crawford SE, Desselberger U. Lipid droplets form complexes with viroplasms and are crucially required for rotavirus replication. Curr Opin Virol 2016; 19: 11-15.

Desselberger U. Reverse genetics of rotavirus. Proc Natl Acad Sci USA 2017 Feb 28;114(9):2106-2108. [Commentary to: Kanai Y, Komoto S, Kawagishi T, Nouda R, Nagawawa N, Onishi M, Matsuura Y, Taniguchi K, Kobayashi T. Entirely plasmid-based reverse genetics system for rotaviruses. Proc Natl Acad Sci USA 2017 Feb 28;114(9):2349-2354.]

Bwogi  J, JereKC, Karamagi C, ByarugabaDK, NamuwulyaP, BaliraineFN , Desselberger U, Iturriza-GomaraM. Whole genome analysis of selected human and animal rotaviruses identified in Uganda from 2012 to 2014 reveals complex genome reassortment events between human, bovine, caprine and porcine strains. PLoS One 2017; 12(6): e0178855.

Desselberger U. At last: A fully tractable, plasmid only-based reverse genetics system for rotavirus. Future Virol 2017; 12(9): 519-524.

Desselberger U. Viral Gastroenteritis. Medicine 2017; 45(11): 690-694. http://dx.doi.org/10.1016/j.mpmed.2017.08.05.

Desselberger U. 7th European Rotavirus Biology Conference, Cork/Ireland, 18-21 June, 2017 (Report). Virus Res 2017; 240: 197-199.

CrawfordSE, RamaniS, TateJE, ParasharUD, SvenssonL, Hagbom M, FrancoMA, GreenbergHB, O’RyanM, KangG, DesselbergerU,  EstesMK. Rotavirus infection. Nature Rev Dis Primers, 2017; 3: 17083.

Desselberger U. Differences of rotavirus vaccine effectiveness by country: likely causes and contributing factors. Pathogens, 2017; 6: E65.

Borodavka A, Desselberger U, Patton J. Genome packaging in multi-segmented dsRNA viruses: distinct mechanisms with similar outcomes. Curr Opin Virol, 2018; 33:106-112.

Desselberger U. The mammalian intestinal microbiome: composition, interaction with the immune system, significance for vaccine efficacy and potential for disease therapy. Pathogens, 2018; 7: E57.

Desselberger U. Virus Taxonomy – a taxing task. Arch Virol, 2018; 163: 2019-2020.

Desselberger U. 13th International Double-Stranded RNA Virus Symposium,

Houffalize/Belgium, 24-28 September 2018. A Meeting Report. J Virol 2019; 93(4). pii: e01964-18.

Desselberger U. Caliciviridae other than Noroviruses. [Special Issue on Noroviruses, S Karst, C Wobus (guest editors)] Viruses 2019,11(3), 286.