Johan Nordgren, Ph.D.

Associate professor (Docent) in Medical Microbiology

Dec 2016 - present -Division of Molecular Virology, Linköping University, Sweden. Research focused on pathogenesis, genetic susceptibility, and epidemiology of enteric viruses

Postdoctoral fellow/researcher in Molecular Virology

2011 – 2016- Division of Molecular Virology, Linköping University, Sweden. Head: Prof. Lennart Svensson, Studies focused on the pathogenesis and molecular epidemiology of noro-and rotaviruses.

Coordinator - Research project in Burkina Faso

2009 – 2011 Saint Camille Medical Centre, University of Ouagadougou, Burkina Faso, West Africa. Head: Prof. Jacques Simpore. Coordination of a research project which investigated the impact, molecular epidemiology and host genetics of viral agents (mainly noro-and rotavirus) causing diarrhea in children in Burkina Faso. The work also included formation of PhD students at the University of Ouagadougou regarding molecular biology as well as statistics and database management.

Ph.D. Medical Microbiology

2005 - 2009 Division of Molecular Medicine, Linköping University, Sweden. Supervisor: Prof. Per-Eric Lindgren. Research regarding norovirus, with a focus on development of detection methods, molecular epidemiology and host genetics. The thesis “Norovirus Epidemiology – Prevalence, transmission and determinants of disease susceptibility”, was defended on April 29th, 2009.

Topic of the presentation- Genetic susceptibility to rotavirus infection –implications for epidemiology and vaccine-take

Infectious diseases have influenced the evolution of the human genome in part by selecting for host alleles that modify infection susceptibility and pathogenesis. The notion that some individuals are more or less susceptible to infections is not new but until relatively recently it was assumed that clinical outcome of an infection was mainly due to virulence factors of the microorganism. Relatively little attention has been given to host genetic factors involved in innate or adaptive immunity or expression of pathogen-specific receptors. Rotavirus is the most common etiological agent of acute gastroenteritis in young children. Despite its high infectivity, a part of the population appear resistant to infection and disease. This pattern of susceptibility is largely mediated by the presence or absence of human histo-blood group antigens on gut epithelial surfaces.  Here I will review and discuss some implications of recent studies on genetic susceptibility to rotavirus infection.